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Korean Circ J. 2002 Feb;32(2):106-117. Korean. Original Article.
Choi EK , Park YB , Oh S , Chae IH , Kim CH , Sohn DW , Oh BH , Lee MM , Choi YS .
Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.
Heart Research Institute, Seoul National University Medical Research Institute, Seoul, Korea.
Cardiovascular Research Laboratory, Seoul National University Hospital, Seoul, Korea.

BACKGROUND AND OBJECTIVES: In order to predict coronary artery disease with clinical factors in type II diabetes, we analyzed the relationship between coronary arterial lesion on coronary angiogram and clinical factors. SUBJECTS AND METHODS: Type II diabetic patients (n=520) were selected from patients who had undergone coronary angiography (CAG) at Seoul National University Hospital. The patient group comprised 461 patients with more than 50% stenosis on CAG and the control group comprised 59 patients with normal CAG. We retrospectively reviewed the measured basic demographics, diabetes statuses, biochemical markers, echocardiographic and coronary angiographic findings. RESULTS: In multivariate analysis, hypertension (p=0.002), smoking (p=0.003), diabetes history longer than 10 years (p=0.030), HbA 1c greater than 7.5% (p<0.001) and HDL-cholesterol level less than 40 mg/dL (p=0.010) were all found to be independent risk factors of coronary artery disease (CAD) on CAG. When the patients were divided into 3 groups according to the number of risk factors, 0 - 1, 2-3 and 4-5, the odd ratios for the second and third groups were 3.0 and 16.0, respectively, compared to that of the first group. The number of risk factors had a positive correlation with the number of diseased vessels. CONCLUSION: In type II diabetic patients, CAD risk factors on CAG were hypertension, smoking, diabetes history longer than 10 years, HbA 1c greater than 7.5%, and HDL-cholesterol level less than 40 mg/dL. The number of risk factors was positively correlated with the presence and severity of CAD on CAG.

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