BACKGROUND AND OBJECTIVES: In order to predict coronary artery disease with clinical factors in type II diabetes, we analyzed the relationship between coronary arterial lesion on coronary angiogram and clinical factors. SUBJECTS AND METHODS: Type II diabetic patients (n=520) were selected from patients who had undergone coronary angiography (CAG) at Seoul National University Hospital. The patient group comprised 461 patients with more than 50% stenosis on CAG and the control group comprised 59 patients with normal CAG. We retrospectively reviewed the measured basic demographics, diabetes statuses, biochemical markers, echocardiographic and coronary angiographic findings. RESULTS: In multivariate analysis, hypertension (p=0.002), smoking (p=0.003), diabetes history longer than 10 years (p=0.030), HbA 1c greater than 7.5% (p<0.001) and HDL-cholesterol level less than 40 mg/dL (p=0.010) were all found to be independent risk factors of coronary artery disease (CAD) on CAG. When the patients were divided into 3 groups according to the number of risk factors, 0 - 1, 2-3 and 4-5, the odd ratios for the second and third groups were 3.0 and 16.0, respectively, compared to that of the first group. The number of risk factors had a positive correlation with the number of diseased vessels. CONCLUSION: In type II diabetic patients, CAD risk factors on CAG were hypertension, smoking, diabetes history longer than 10 years, HbA 1c greater than 7.5%, and HDL-cholesterol level less than 40 mg/dL. The number of risk factors was positively correlated with the presence and severity of CAD on CAG.