May-Thurner syndrome (iliac vein compression syndrome) is an uncommon condition in which the right common iliac artery compresses the left common iliac vein against the pelvic rim, resulting in left iliofemoral deep vein thrombosis and severe leg edema. Serious vascular sequelae to the leg can result if this condition is not recognized and corrected in a timely fashion. Several new interventions for treating May-Thurner syndrome have emerged over the past several years. Catheter-directed thrombolysis and stenting have been advocated as effective for the treatment of acute thrombosis and the underlying stenosis of May-Thurner syndrome. We report two cases of May-Thurner syndrome that were treated with catheter-directed thrombolysis and stent implantation.