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J Korean Pediatr Soc. 1998 Oct;41(10):1430-1432. Korean. Case Report.
Park EH , Cho HS , Yoo HS , Lyu CJ , Yang CH , Kim KY .
Department of Pediatrics, College of Medicine, Yonsei University, Korea.
Department of Pediatrics, Kangdong Sacred Heart Hospital, College of Medicine, Hallym University, Seoul, Korea.
Department of Pediatrics, Kunpo Medical Center, College of Medicine, Wonkwang University, Kunpo, Korea.

Inappropriate secretion of antidiuretic hormone (ADH) secondary to vincristine therapy has been reported frequently. But there has been five previous reports of vinblastine associated SIADH in the world and in 4 reports, bleomycin and cis-platinum were used along with vinblastine together. Because penetration of vinka alkaloids into CSF of humans is known to be poor, it has been suggested that lowering the osmotic threshold for vasopressin release induces SIADH in humans. In our case, the patient did not receive cis-platinum during chemotherapy. From this we concluded that vinblastine alone can induce SIADH without nephrotoxicity of cis-platinum. We experienced a case of inappropriate ADH secretion secondary to vinblastine therapy in a 5- month-old male infant who has been taking vinblastine due to Langerhans cell histiocytosis. We report this case with a brief review of related literatures.

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