Ceftriaxone, a potent third-generation semisynthetic cephalosporine, is widely used for treatment various bacterial infections in children. There have been some reports that transient appearance of gallbladder sludge was often demonstrated by abdominal sonography in patients treated with ceftriaxone. Reversible biliary pseudolithiasis was used to describe this phenomenon. We present a case of biliary pseudolithiasis which appeared to be related to intravenous ceftriaxone therapy in children who received ceftriaxone to treat meningitis. The recommended ceftriaxone dose was 100mg/kg/day and a total duration of administrations was 21 days. Abdominal sonographic examination showed nothing prior to antibiotic therapy, however, multiple tiny hyperechogenic materials were observed in gallbladder on day 7 of treatment. This patient did not demonstrate any symptoms. Follow-up abdominal sonography examination revealed that gallbladder materials began to resolve spontaneously on third day of posttherapy and complete resolution was observed on day 13 after cessation of ceftriaxone therapy.