Impression of hypopituitarism based on clinical data, were confirmed in six patients aged gormone release. An exercise test was performed as screening test and argininine insulin treatment with hGH wu, I.M. 3 times per week for a year to tone and half years. Growth rates of 9~10 cm/year were ween during the first year of therapy. These rates were 2~2.5 times greater than those observed during pre or post treatment periods.