One case of the staphylococcal scalded skin syndrome was reported in 15 days old female newborn infant. Since 5 days prior to admission, she was suffered from high fever, irritability, and generalized vesicobullous skin lesions which were suddenly developed. We isolated Staphylococcus epidermidis from bullous lesions. The patient was completely recovered with systemic and local supportive care. We also reviewed briefly related literatures.