Numerous problems has not been solved in the field of pulmonary tuberculosis, especially in chemotherapy. There has been many turning points in the treatment of pulmonary tuberculosis such as; introduction of streptomycin, combination therapy, isoniazid single therapy, intermittent chemotherapy, and recent short-term chemotherapy. It is very important to know about individual drugs for the better chemotherapy. So a review has been made referring many literatures in pharmacologic properties of them. Also single INH therapy, double chemotherapy and triple chemotherapy have be described.