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Anat Cell Biol. 2013 Jun;46(2):122-130. English. Original Article. https://doi.org/10.5115/acb.2013.46.2.122
Sakr SA , Nooh HZ .
Department of Zoology, Faculty of Science, Menoufia University, Shebin El-kom, Egypt. sabsak@yahoo.com
Department of Anatomy and Embryology, Faculty of Medicine, Menoufia University, Shebin El-kom, Egypt.
Abstract

The present study examined the efficacy of Ocimum basilicum (basil) extract, a natural herb, with antioxidant properties, against testicular toxicity induced by cadmium (Cd), which is one of the most important toxic heavy metals. The intoxicated rats showed significant alterations in the testicular tissue including decreased seminiferous epithelium height and changes in the arrangement of spermatogenic layers. Hypospermatogensis with cytoplasmic vacuolization and pyknotic nuclei were observed. Intertubular hemorrahage and absence of spermatozoa were noted. Decreased cell proliferation was reflected by a decrease in Ki-67 expression, whereas the increase in apoptotic rate was associated with a decrease in the Bcl/Bax ratio. Concomitant treatment with aqueous basil extract led to an improvement in histological, morphometrical and immunohistochemical changes induced by Cd. The beneficial effects of basil extract could be attributed to its antioxidant properties.

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