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Korean J Pain. 2015 Jul;28(3):198-202. English. Clinical Trial. https://doi.org/10.3344/kjp.2015.28.3.198
Haghighi M , Sedighinejad A , Mirbolook A , Naderi Nabi B , Farahmand M , Kazemnezhad Leili E , Shirvani M , Khajeh Jahromi S .
Anesthesiology Research Center, Guilan University of Medical Sciences, Rasht, Iran.
Orthopedic Research Center, Guilan University of Medical Sciences, Rasht, Iran. ahmadreza.mirbolook@gmail.com
Guilan University of Medical Sciences, Rasht, Iran.
Guilan Trauma Research Center, Guilan University of Medical Sciences, Rasht, Iran.
Qazvin University of Medical Sciences, Qazvin, Iran.
Abstract

BACKGROUND: Lack of proper control of acute postoperative pain often leads to lingering or chronic pain. Several studies have emphasized the role of beta-blockers in reducing postoperative pain. Esmolol is a selective short-acting beta-blocker that produces few side effects. The purpose of this study was to examine the effect of intravenous intraoperative esmolol on postoperative pain reduction following orthopedic leg fracture surgery. METHODS: In a clinical trial, 82 patients between 20-65 years of age with tibia fractures and American Society of Anesthesiologists (ASA) physical status I & II who underwent surgery were divided into two groups. Group A received esmolol and group B received normal saline. Postoperative pain was measured at three time points: entering the recovery unit, and at 3 h and 6 h following surgery, using the Visual Analogue Scale (VAS). A P value of < 0.05 was considered significant. RESULTS: Mean VAS scores at all three time points were significantly different between the two test groups (P = 0.02, P = 0.0001, and P = 0.0001, respectively). The consumption of pethidine was lower in group A than in group B (P = 0.004) and the duration of its effect was significantly longer in time (P = 0.026). CONCLUSIONS: Intravenous intraoperative esmolol is effective in the reduction of postoperative pain following leg fracture surgery. It reduced opioid consumption following surgery and delayed patient requests for analgesics.

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