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J Korean Soc Med Ultrasound. 2003 Dec;22(4):223-232. Korean. Original Article.
Kim SM , Park JM , Lee SH , Han H , Song HY , Shin JH , Kim TH , Gong G , Kim HJ , Kim KR , Kim JW , Kim HH , Yoon HS , Seo MH .
Department of Radiology, Asan Medial Center, University of Ulsan College of Medicine, Korea.
Department of Radiology, Kangwon National University College of Medicine, Korea.
Department of Pathology, Asan Medial Center, University of Ulsan College of Medicine, Korea.
Department of Radiology, Military Gwangju Hospital, Korea.

PURPOSE: To determine the usefulness and complications of a newly made metallic tissue marker inserted after mammotome biopsy of breast lesions. MATERIALS AND METHODS: We manufactured a new gold tissue marker and introducer for the insertion after ultrasound-guided mammotome biopsy for breast lesions. The new tissue marker was inserted to 7 dogs and 22 patients. Histopathologic findings were evaluated in all dogs and patients with malignant diseases who underwent surgery. Follow-up mammography and ultrasonography were performed in patients with benign diseases 6 months after the biopsy for the evaluation of complications including migration. RESULTS: In dogs, there was no foreign body reaction in 3 dogs, mild foreign body reactions in 3 dogs, and moderate foreign body reactions in one dog. Meanwhile, the marker was successfully inserted in 17 (77.3%) of 22 patients under ultrasonography-guidance. There were mild foreign body reactions in 4 patients with malignant diseases. On one month follow-up mammography and ultrasonography in 12 of 13 patients with benign diseases with the successful marker insertion showed hematoma with the size ranging from 8 to 23 mm in 8 patients (66.7%). Rotation of the marker without any change of location was seen in 4 patients while rotation with the changed location, about 1cm in distance, was seen in 1 patient. On six month follow-up ultrasongraphy performed in 9 patients showed the disappearance of all hematomas. There was no change of the marker's location on mammography compared to the one-month follow-up mammography. Pain or inflammatory reaction was not noted in any patient. CONCLUSION: This new gold post-mammotome tissue marker showed mild foreign body reaction and no significant complication including migration. It will be very useful in routine practice of mammotome for breast lesions.

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