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Ann Rehabil Med. 2019 Feb;43(1):54-61. English. Original Article. https://doi.org/10.5535/arm.2019.43.1.54
Han SH , Cho IK , Jung JH , Jang SH , Lee BS .
Department of Physical Medicine and Rehabilitation, National Rehabilitation Center, Seoul, Korea. iambs@nrc.go.kr
Department of Physical Medicine and Rehabilitation, Hanyang University College of Medicine, Seoul, Korea.
Abstract

Objective

To evaluate the long-term efficacy of mirabegron add-on therapy in patients with spinal cord injury (SCI) based on an urodynamic study.

Methods

This retrospective study involved a chart audit of individuals with SCI who underwent two consecutive urodynamic studies between April 1, 2015 and April 1, 2018. After adding 50 mg of mirabegron once a day to the pre-existing antimuscarinic therapy for a period of, at least 6 months, the following variables were analyzed: change in cystometric capacity, change in bladder compliance, change in maximal detrusor pressure, change in reflex volume, and presence of significant leakage during filling cystometry.

Results

A total of 31 participants with a mean age of 41±15 years were included in the analysis. A significant increase in cystometric capacity (mean, 362 to 424 mL; p=0.03), reflex volume (mean, 251 to 329 mL; p=0.02), and bladder compliance (median, 12 to 18 mL/cmH₂O; p=0.04) was observed. The presence of leakage during filling cystometry was significantly reduced (29% to 10%; p=0.03). Likewise, a non-significant decrease in the change in maximal detrusor pressure was observed (mean, 31 to 27 cmH₂O; p=0.39).

Conclusion

Adding mirabegron to conventional antimuscarinics further improved urodynamic parameters in patients with chronic SCI, and sustained efficacy was observed in long-term use.

Copyright © 2019. Korean Association of Medical Journal Editors.