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Ann Rehabil Med. 2012 Jun;36(3):340-346. English. Original Article.
Jeung IS , Lee S , Kim HS , Yeo CK .
Department of Rehabilitation Medicine, Dongsan Medical Center, Keimyung University School of Medicine, Daegu 700-712, Korea. sylee@dsmc.or.kr
Department of Pediatrics, Dongsan Medical Center, Keimyung University School of Medicine, Daegu 700-712, Korea.
Department of Otolaryngology, Dongsan Medical Center, Keimyung University School of Medicine, Daegu 700-712, Korea.
Abstract

OBJECTIVE: To determine the 9 month period effect of botulinum toxin A (BoNT-A) injection into the salivary gland in children with neurologic disorders and sialorrhea by qualified parent/caregiver-administered questionnaires. METHOD: A total of 17 patients (age 7.6+/-4.24 years) were enrolled in this study. The degree of sialorrhea was assessed at the baseline, 2 weeks, 1, 2, 4, 6 and 9 months after injection. The Drooling Count (DC) was assessed as an objective measurement. The Drooling Frequency and Severity Scale (DFS) and the Teacher Drooling Scale (TDS) were evaluated as a subjective measurement. BoNT-A (0.5 unit/kg) was injected into each submandibular and parotid gland under ultrasonography-guidance. RESULTS: DC, DFS and TDS showed significant improvement at 2 weeks, 1, 2, 4, 6, and 9 months follow-up (p<0.05). Twelve of 17 cases (70.5%) showed more than 50% reduction in DC from the baseline value. CONCLUSION: Ultrasonography-guided BoNT-A injection into the submandibular and parotid gland was a safe and effective method to treat sialorrhea in children with neurologic disorders.

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