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Investig Magn Reson Imaging. 2017 Dec;21(4):223-232. English. Original Article. https://doi.org/10.13104/imri.2017.21.4.223
Seo HS , Jang KE , Wang D , Kim IS , Chang Y .
Department of Radiology, Korea University Ansan Hospital, Gyeonggi-do, Korea.
Department of Medical & Biological Engineering, Kyungpook National University, Daegu, Korea.
MR R&D, Siemens Medical Solutions USA, Inc., Minneapolis, Minnesota, USA.
Radiology University of Minnesota, Minneapolis, Minnesota, USA.
Siemens Healthcare Ltd., Seoul, Korea.
Department of Radiology, Kyungpook National University Hospital, Daegu, Korea. ychang@knu.ac.kr
Department of Molecular Medicine, Kyungpook National University School of Medicine, Daegu, Korea.
Abstract

Purpose

To report the use of multiband accelerated echo-planar imaging (EPI) for resting-state functional MRI (rs-fMRI) to achieve rapid high temporal resolution at 3T compared to conventional EPI.

Materials and Methods

rs-fMRI data were acquired from 20 healthy right-handed volunteers by using three methods: conventional single-band gradient-echo EPI acquisition (Data 1), multiband gradient-echo EPI acquisition with 240 volumes (Data 2) and 480 volumes (Data 3). Temporal signal-to-noise ratio (tSNR) maps were obtained by dividing the mean of the time course of each voxel by its temporal standard deviation. The resting-state sensorimotor network (SMN) and default mode network (DMN) were estimated using independent component analysis (ICA) and a seed-based method. One-way analysis of variance (ANOVA) was performed between the tSNR map, SMN, and DMN from the three data sets for between-group analysis. P < 0.05 with a family-wise error (FWE) correction for multiple comparisons was considered statistically significant.

Results

One-way ANOVA and post-hoc two-sample t-tests showed that the tSNR was higher in Data 1 than Data 2 and 3 in white matter structures such as the striatum and medial and superior longitudinal fasciculus. One-way ANOVA revealed no differences in SMN or DMN across the three data sets.

Conclusion

Within the adapted metrics estimated under specific imaging conditions employed in this study, multiband accelerated EPI, which substantially reduced scan times, provides the same quality image of functional connectivity as rs-fMRI by using conventional EPI at 3T. Under employed imaging conditions, this technique shows strong potential for clinical acceptance and translation of rs-fMRI protocols with potential advantages in spatial and/or temporal resolution. However, further study is warranted to evaluate whether the current findings can be generalized in diverse settings.

Copyright © 2019. Korean Association of Medical Journal Editors.