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Korean J Clin Pathol. 2001 Jun;21(3):176-182. Korean. Randomized Controlled Trial.
Song KE , Chae SC , Jun JE , Park WH , Chun BY , Joung HJ , Choi YS , Cho SH .
Department of Clinical Pathology, School of Medicine, Kyungpook National University, Taegu, Korea.
Department of Internal Medicine, School of Medicine, Kyungpook National University, Taegu, Korea.
Department of Preventive Medicine, School of Medicine, Kyungpook National University, Taegu, Korea.
Department of Culinary Science, Honam University, Kwangju, Korea.
Department of Food and Nutrition, Taegu University, Taegu, Korea.
Department of Food and Nutrition, Taegu Catholic University, Taegu, Korea.
Abstract

BACKGROUND: The oxidative modification of lipids and the endothelial expression of adhesion molecules are key events in the pathogenesis of atherosclerosis. The appropriate antioxidants that protected and slowed the progression of the disease were reported. We measured the antioxidant enzyme activities and the levels of soluble cellular adhesion molecules in order to evaluate whether antioxidant vitamin supplementation affected the oxidative changes and the expression of cellular adhesion molecules. METHODS: Seventy-seven patients participated in a randomized, double blind, placebo-controlled trial. The test group (38 patients) was given antioxidant vitamin doses including a daily dose of vitamin C 500 mg, beta-carotene 15 mg, vitamin E 400 IUs, and selenium 50 microgram, The control group (44 patients) received placeboes for three months. We measured the vitamin serum levels, intercellular adhesion molecules-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1), E-selectin and activities of erythrocyte enzymes such as superoxide dismutase (SOD), catalase, and glutathione peroxidase (GPX) before and at 3 months after supplementation. RESULTS: After supplementation, the serum vitamin levels increased significantly (P<0.05) and the activity of the erythrocyte SOD significantly increased by 0.85 unit/mg hemoglobin (P<0.05) in the test group. Soluble ICAM-1, VCAM-1 and E-selectin levels did not change significantly in the test group after supplementation. CONCLUSIONS: These results suggest that the antioxidant vitamin supplementation may affect erythrocyte SOD activity, but not soluble cellular adhesion molecule levels.

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