Vibrio vulnificus infections occur between May and October, and most often involve men over age 40. V. vulnificus has been linked to two distinct syndromes: primary sepsis and primary wound infections. Primary sepsis occurs most commonly in patients with antecedent liver disease such as cirrhosis. Mortality approaches about 50 percent, with most deaths due to uncontrolled sepsis. We experienced a case of septicemia without dermatologic lesion by serovar type O1 V. vulnificus, and reported this case with a review of literature.