Spontaneous renal artery dissection (SRAD) is a rare event, which may be a challenge to physicians due to its rarity and nonspecific clinical presentation. We report two cases of SARD who were previously healthy men and complicated with renal infarction. Both presented with acute flank pain and high blood pressure. One was diagnosed by abdominal computed tomography and treated conservatively. The other was confirmed to have right renal artery dissection by selective arteriography and underwent renal artery stenting. Conservative treatment with antihypertensives and anticoagulantion usually bring up satisfactory results in most cases, but revascularization may be indicated for patients who have uncontrolled hypertension, renal insufficiency as a consequence of the dissection, or bilateral renal artery dissection.