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Korean J Nephrol. 2001 Jul;20(4):719-722. Korean. Original Article.
Lee JI , Kang TY , Cho HP , Yoon CO , Jung CI , Lee SJ , Kang MS , Lee CH , Kahng KW , Park CH , Kang CM , Lee WS .
Department of Internal Medicine, Hanyang University School of Medicine, Seoul, Korea.
Department of Clinical Pathology, Hanyang University School of Medicine, Seoul, Korea.

Parvovirus B19 infection is known to cause chronic anemia in immunocompromised hosts, including organ transplant recipients. We report a case of pure red cell aplasia caused by parvovirus B19 in renal transplants. The patient was 16-year-old male who was diagnosed as chronic renal failure 7 years ago and had been on hemodialysis twice a week. He got renal transplantation in June 1999. But anemia was not improved in first postoperative period. On admission hemoglobin was 43.0 g/L, hematocrit was 12.7%. The bone marrow biopsy revealed severe erythroid hypoplasia with giant pronormoblasts. The pronormoblasia with giant prominent intranuclear inclusions, characteristic of parvovirus B19 infection. The parvovirus B19 PCR and anti-parvovirus B19 IgM were positive. The patient was treated with intravenous immunoglobulin and then reticulocyte count was increased 5 days later. Hemoglobin level restored to 104 g/L teo months later.

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