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J Korean Neurosurg Soc. 2018 May;61(3):376-385. English. Review. https://doi.org/10.3340/jkns.2018.0057
Bae JM , Won JK , Park SH .
Department of Pathology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea. shparknp@snu.ac.kr jkwon@snuh.org
Department of Neuroscience Institute, Seoul National University College of Medicine, Seoul, Korea.
Abstract

Recent discoveries of brain tumor-related genes and fast advances in genomic testing technologies have led to the era of molecular diagnosis of brain tumor. Molecular profiling of brain tumor became the significant step in the diagnosis, the prediction of prognosis and the treatment of brain tumor. Because traditional molecular testing methods have limitations in time and cost for multiple gene tests, next-generation sequencing technologies are rapidly introduced into clinical practice. Targeted sequencing panels using these technologies have been developed for brain tumors. In this article, focused on pediatric brain tumor, key discoveries of brain tumor-related genes are reviewed and cancer panels used in the molecular profiling of brain tumor are discussed.

Copyright © 2019. Korean Association of Medical Journal Editors.