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J Korean Neurosurg Soc. 2009 Mar;45(3):151-156. English. Original Article.
Balak N , Isiksacan N , Turkoglu R .
Department of Neurosurgery, Bakirkoy Sadi Konuk Education and Research Hospital, Istanbul, Turkey. naci.balak@attglobal.net
Department of Biochemistry, Bakirkoy Sadi Konuk Education and Research Hospital, Istanbul, Turkey.
Department of Neurology, Haydarpasa Numune Education and Research Hospital, Istanbul, Turkey.
Abstract

OBJECTIVE: It is well known that changes in cerebral hemodynamics occur after traumatic brain injury (TBI). Osmo-regulation in the brain is important for maintaining a constant milieu in the central nervous system. Nevertheless, to our knowledge, early osmolarity changes after minor head injury have not been studied until now. METHODS: In this study, serum osmolarity was measured in 99 patients with minor head trauma. As a control group, blood samples were drawn from 99 patients who had a minor trauma in an extremity. Serum osmolarity was estimated using a fully automatic biochemical autoanalyzer within the first 3 hours after the trauma. RESULTS: The mean serum osmolarity levels were 286.08+/-10.17 mOsm/L in the study group and 290.94+/-5.65 mOsm/L in the control group (p<0.001). However, after age adjustment between the study and control groups, this statistical significance was found to be valid only for patients over 30 years of age. CONCLUSION: It was noted that serum osmolarity levels decrease in the first 3 hours following minor head trauma in patients over 30 years of age. Further studies into this area could provide guidance for the management/treatment of elderly patients.

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