Hippocampal sclerosis is the most common abnormal pathologic substrate found in patients with intractable temporal lobe epilepsy. Histopathological findings of hippocampal sclerosis are characterized by the presence of neuronal cell loss and astrocytic proliferation in the facsia dentata, Ammon's horn, presubiculum, and subiculum. Despite numerous studies having been conducted, the pathogenesis of hippocampal sclerosis is still controversial. Recently, it has been reported that increased numbers of corpora amylacea can be found in the hippocampus, the gray and white matter of the temporal lobe, in association with hippocampal sclerosis, which may give another clue to the pathogenesis of the hippocampal sclerosis. The authors report 3 patients with medically intractable temporal lobe epilepsy with hippocampal sclerosis in association with an increased numbers of corpora amylacea in the temporal white matter.