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J Korean Neurosurg Soc. 2002 Mar;31(3):234-240. Korean. Original Article.
Kim MS , Chung CK , Kim HJ , Kim SS , Choe G , Chi JG .
Department of Neurosurgery, Seoul National University College of Medicine, Seoul, Korea.
Department of Radiology, Seoul National University College of Medicine, Seoul, Korea.
Department of Pathology, Seoul National University College of Medicine, Seoul, Korea.
Abstract

OBJECTIVE: To provide the better treatment guideline for spinal cord astrocytomas, the authors present a retrospective analysis of our series. METHODS: We managed 28 patients(mean age 36 years) in our institute from 1978 through 1999. Nineteen patients received radiation therapy after biopsy or resection. Gross total removal was performed in three cases. The median follow-up period was 6.5 months(range, 0.5-184 months). RESULTS: Low-grade astrocytomas were found in 18 cases, anaplastic astrocytoma in three cases and glioblastomas in seven cases. The cumulative survival of patients with low grade astrocytoma was 62.3% at 8.5 years and the cumulative survival of patients with high grade glioma was 19.1% at 11 months (p=0.0017). The overall survival of irradiated patients with low grade astrocytoma was 88% at six months, and the overall survival of non-irradiated patients with low grade astrocytoma was 60% at eight months(p=0.0565). Neither the extent of resection, nor the location of tumor influenced the survival rate (p=0.468 and p=0.8632, respectively). CONCLUSION: Histological grade was the most significant predictor of survival in patients with astrocytoma of the spinal cord. Postoperative radiation therapy in low-grade astrocytomas tended to improve the survival rate.

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