The authors have performed simple CT-guided free-hand tumor biopsy. CT images and C-arm fluroscopy were taken to determine the coordinates of the target point, which was the center of the tumorous CT findings. This CT-guide stereotaxic approach for biopsy of intracranial tumors have the following advantages: 1) The procedure is simple and safe. 2) The operation can be performed under local anesthesia. 3) The operation can be performed without stereotaxic frame. 4) Tissue biopsy was taken on various sites of tumors. The authors have performed 4 cases as follow: 3 cases of anaplastic astrocytoma, 1 case of metastatic tumor. Neither mortality nor morbidity was noted.