Journal Browser Advanced Search Help
Journal Browser Advanced search HELP
Korean J Gastroenterol. 2012 Apr;59(4):268-274. Korean. Review. https://doi.org/10.4166/kjg.2012.59.4.268
Chung WJ .
Department of Internal Medicine, Keimyung University School of Medicine, Daegu, Korea. chung50@dsmc.or.kr
Abstract

Insulin resistance is frequently associated with chronic liver disease, and the interaction between hepatitis C virus (HCV) infection and insulin resistance is a major public health issue, bound to increase in the near term. Because of their potential synergism on liver disease severity, a better understanding of the clinical consequences of the relationship between HCV infection and insulin resistance is needed. This translates into accelerated liver disease progression, reduced response to anti-viral agents and, in susceptible individuals, increased risk of developing type 2 diabetes. HCV may also cause hepatic steatosis, especially in patients infected with genotype 3, although the clinical impact of viral steatosis is debated. Little is known regarding the effect of anti-diabetic agents on HCV infection, and a possible association between use of exogenous insulin or a sulfonylurea agents and the development of hepatocellular carcinoma has recently been reported. Thus, modified lifestyle and pharmacological modalities are urgently warranted in chronic hepatitis C with metabolic alterations.

Copyright © 2019. Korean Association of Medical Journal Editors.