Most duodenal diverticuli are asymptomatic and incidentally found. The incidence of duodenal diverticulum varies from 5% to 23% in the general population by upper gastrointestinal series or upper gastrointestinal endoscopy. It usually occurs in the medial part of the duodenum with complications such as hemorrhage, perforation, biliary stones, ulceration, obstruction. Hemorrhage is a rare complication in patients with duodenal diverticulum. Some authors have implicated ectopic gastric mucosa, stasis-induced ulceration, or erosion into a major vessel for the etiologies of bleeding in duodenal diverticulum. There is a strong relationship between Helicobacter pylori (H. pylori) infection and peptic ulcer disease. However, it is not clear whether H. pylori eradication can be used for treating intradiverticular ulcer in patients with H. pylori infection. We report a case of treatment and prevention of rebleeding due to a duodenal intradiverticular ulcer after H. pylori eradication therapy.