hepatocellular carcinoma. A 62-year-old man was diagnosed as a hepatocellular carcinoma by abdo minal computerized tomography (CT) and the elevated serum alpha-fetoprotein (alpha FP) concentration. He refused further evaluation involving biopsy and was treated with conventional drug, silymarin and ursodeoxycholic acid. In abdominal CT performed 2 months after initial diagnosis, tumor mass markedly regressed and serum alpha FP level was remarkably decreased, too. At the 6th month from the initial diagnosis, tumor subsequently regressed to near-normal state and alpha FP level was normalized Thereafter, he felt good and continued conventional medication. At the 21st month from the initia diagnosis, the 15th month after tumor regression, multiple liver masses were found on abdominal CT at different site from the initial tumor. However, serum alpha FP was within normal range. We performed transcatheter arterial chemoembolization three times. At present, 26 months after the initial diagnosis the patient is living well.