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Korean J Pathol. 2012 Jun;46(3):287-291. English. Case Report.
Park ES , Kim YE , Park CK , Yao T , Kushima R , Kim KM .
Department of Hospital Pathology, Incheon St. Mary's Hospital, The Catholic University of Korea School of Medicine, Korea.
Department of Pathology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. km7353.kim@samsung.com
Department of Human Pathology, Juntendo University, Tokyo, Japan.
Clinical Laboratory Division, National Cancer Center Hospital, Tokyo, Japan.
Abstract

Recently, fundic gland type gastric adenocarcinoma (GA-FG) has been reported as a new entity. This report describes GA-FG among Koreans for the first time. From March 2008 to July 2010 we identified only three cases of GA-FG out of over 6,000 GAs resected by endoscopy or surgery. Cell differentiation by mucin proteins, pepsinogen-I, and H+/K+-ATPase was evaluated. All three cases were male patients and diagnosed as early stage GA. Histologically, GA-FGs were well-differentiated adenocarcinoma with pale gray-blue, basophilic columnar or cuboidal cells and mildly enlarged nuclei, resembling chief cells. All three cases were positive for pepsinogen-I and were classified as gastric mucin phenotype. Among three histologic subtypes of GA-FG, since tumors were mainly composed of chief cells, our three cases were classified as chief cell predominant type. In conclusion, GA-FG is very rare among Koreans and pepsinogen-I and MUC6 expression are typical immunohistochemical findings in GA-FG suggesting differentiation toward fundic glands.

Copyright © 2019. Korean Association of Medical Journal Editors.