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J Korean Soc Ther Radiol. 1997 Mar;15(1):19-26. Korean. Original Article.
Ahn YC , Lim DH , Choi DR , Kim MK , Kim DY , Huh SJ , Baek CH , Chu KC , Yoon SS , Park K .
Department of Radiation Oncology, Samsung Medical Center, College of Medicine, Sung Kyun Kwan University, Korea.
Department of Otorhinolaryngology-Head & Neck Surgery, Samsung Medical Center, College of Medicine, Sung Kyun Kwan University, Korea.
Department of Hematology/Oncology, Samsung Medical Center, College of Medicine, Sung Kyun Kwan University, Korea.
Abstract

PURPOSE: This study is to report experience with Fractionated Stereotactic Radiation Therapy (FSRT) for locally recurrent nasopharynx cancer after curative conventional radiation therapy. MATERIALS AND METHODS: Three patients with locally recurrent and symptomatic nasopharynx cancer were given FSRT as reirradiation method between the period of September of 1995 and August of 1996. For two patients, application of FSRT is their third radiation therapy directed to the nasopharynx. Two patients were given low dose chemotherapy as radiation sensitizer concurrently with FSRT. Authors used 3-dimensional coordinate system by individually made, relocatable Gill-Thomas-Cosman (GTC) stereotactic frame and multiple non-coplanar arc therapy dose planning was done using XKnife-3. Total of 45 Gy/18 fractions or 50 Gy/20 fractions were given. RESULTS: Authors observed satisfactory symptomatic improvement and remarkable objective tumor size decrease by follow-up MR images taken 1 month post-FSRT in all three patients, while no neurologic side effect attributable to reirradiation was noticed. Two died at 7 and 9 months with loco-regional and distant seeding outside FSRT field, while one patient is living for 4 month. CONCLUSION: Authors experienced satisfactory therapeutic effectiveness and safety of FSRT as reirradiation method for locally recurrent nasopharynx cancer. Development of more effective systemic chemotherapeutic regimen is desired for distant metastasis.

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