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J Korean Soc Ther Radiol. 1990 Dec;8(2):151-154. English. Original Article.
Kang CH , Kum SK , Shin SO , Kim MS .
Department of Therapeutic Radiology, College of Medicine, Yeungnam University, Taegu, Korea.

The acute effects of variable dos rates to total body irradiation (TBI) were investigated with 600 cgy of single exposure in the mice as a preclinical model. Total 80 mice (ICR) were used. Twenty of which served as controls, receiving no irradiation. All irradiated mice showed a universal decline in their weight and white blood cell count. The degree of weight loss and leukopenia were similar at 3 different dos rate but slightly prominent with 15 cgy/minute group. The degree of recovery among the groups showed no dose rate dependence. Our results suggest that TBI with 15 cgy/minute may be applicable for clinical therapy with careful evaluation of patient's condition.

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