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J Korean Radiol Soc. 2007 Oct;57(4):315-322. Korean. Original Article.
Jun JS , Kim HJ , Yang PS , Choi CG , Kim SJ , Lee JH , Lee SB , Ryu SY , Kim JC .
Deparment of Radiology, Dae Jeon, St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Korea.
Department of Radiology, Asan Medical Center, University of Ulsan College of Medicine, Korea.
Deparment of Neurology, Dae Jeon, St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Korea.

PURPOSE: To evaluate the effect of changes of parameters of diffusion tensor imaging (DTI), including slice thickness/slice number, b-value and the direction number of a diffusion gradient on fractional anisotropy (FA). MATERIALS AND METHODS: Three groups of normal volunteers underwent brain diffusion tensor imaging with the use of three different imaging parameters as follows: a different slice thickness/slice number (6 mm/20 slices and 2.33 mm/54 slices), a different b-value (800 s/mm2/1000 s/mm2) and a different number of directions of the diffusion gradient (6 and 15 directions). The signal to noise ratio (SNR) and FA were measured by a ROI measurement at the anterior corona radiata, superior corona radiata, putamen and corpus callosum. We compared the mean SNR and FA in each group by the use of the paired T-test. RESULTS: The SNR decreased and the FA increased significantly according to the increase of the slice number (6 mm/20 slices vs. 2.33 mm/54 slices). The SNR of DTI with 15 diffusion gradient directions was significantly higher than DTI with six directions, without a difference of FA. There were no significant changes of the SNR and FA of DTI according to the b-value. CONCLUSION: It is essential and useful in the clinical application of DTI to understand the effect of imaging parameters on FA.

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