Sialography is a valuable diagnostic procedure in accurate diagnosis and therapeutic planning of the diseasesof major salivery glands. The purpose of this paper is to review the technical aspect of method and to evaluateestablished diagnostic criteria in various abnormalities of major salivary glands. Authors present 25 cases ofsialography which has been routinely performed in those patients with recurrent swelling pain, mass or anycombination of these signs and symptoms in the are of major salivary glands at National Medical Center from May1975 to June 1980. The reuslts were as follows; 1. 2 cases of the stone and stricture, which were easily diagnosedby the filling defect, obstruction and dilatation or irregular narrowing of the main duct of salivary gland, werein the submaxilary gland. 2. 7 cases of the inflammation in major salivary glands revealed "pruned tree" appearance, and irregular caliber and shape of intraglandular ducts, and punctate or globular dilatation of theinterlobular ductules and acini. 3. Among the 5 cases of salivary gland tumors, 4 cases were in the parotid gland.Sialographic finding showed displacement of the duct, nonopacified are and puddling or pooling of the contrastmaterial in the gland parenchyme. 4. The retention of the contrats material in postevacuation film and destructionof duct architecture were important findings in differentiation of inflammation and tumors of major salivaryglands.