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Korean J Anesthesiol. 2005 Jun;48(6):587-591. Korean. Original Article.
Kim CM , Jeong ST , Kim SJ , Bae HB , Choi JI , Jeong SW , Chung SS , Yoo KY , Jeong CY , Yoon MH .
Department of Anesthesiology and Pain Medicine, Medical School, Chonnam National University, Gwangju, Korea. mhyoon@chonnam.ac.kr
Department of Anesthesiology School of Dentistry, Chonnam National University, Gwangju, Korea.
Abstract

BACKGROUND: The present study was designed to examine the effect of a combination of nicardipine and low dose alfentanil on hemodynamic response following endotracheal intubation. METHODS: Thirty patients (20-65 yr) were assigned randomly to receive nicardipine (N: 20microgram/kg) or a combination of nicardipine and low dose of alfentanil (NA: nicardipine 10microgram/kg and alfentanil 5microgram/kg). Systolic blood pressure (SBP), diastolic blood pressure (DBP) and heart rate (HR) were measured at 1, 2 min after anesthetic induction, and every minute for 5 min after intubation. RESULTS: The magnitude of increases in SBP and DBP were non-significantly smaller in the NA group than in the N group, and increase in HR were significantly lower in the NA group. CONCLUSIONS: These results indicate that the nicardipine with alfentanil combination was more effective than nicardipine alone at attenuating blood pressure and heart rate increases following intubation.

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