Cushing's syndrome is a clinical and metabolic disorder resulting from chronic excess of glucocorticoids. Therefore anesthetic problems likely to present are those related to diabetes, hypokalemia, osteoporosis and arterial hypertension. After premedication with Solu-Cortef 100mg. valium 10mg and morphine 10mg i.m. one hour and propranolol 1mg i.v. injection 10 minutes. peroperatively. induction was commenced with thiopental 200mg i.v. followed by succinylcholine 50 mg i.v. Anesthesia was maintained with halothane, N2O. pancuronium and oxygen using endotracheal semiclosed circle absorption techniques with controlled ventilation. The patient tolerated the anesthesia and surgery well without gross pre and post operative complications. It is thought that fluid and electolyte balance, heavy sedation, prevention of hypo-& hyperglycemia, smooth induction, adequate alveolar ventilation and proper cardiovascular control are important for Cushing's syndrome.