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Korean J Anesthesiol. 1979 Mar;12(1):11-15. Korean. Original Article.
Kim DK , Sohn IJ .
Department of Anesthesiology, College of Medicine, Chosun University, Kwangju, Korea.

This study was undertaken to investigate the effect of premedicants, diazepam and atropine sulfate in ten surgical patients by determining human plasma thyroxine levels. Tetrasorb-125 was utilized as a kit which offers a method for quantitative measurement of total circulating serum thyroxine. The plasma thyroxine level before administration of premedicants was 11. 16+/-2. 45ug/100ml and at 60 minutes after administration of premedicants. it was 11. 3+/-2. 73ug/100ml so that clinical significance of the result was absent. The number of male and female patients was 3 and 7, mean age 40. 1+/-9. 82 and average body weight 56. 1+/-4. 01kg. Consequently there was no significant change in human plasma thyroxine during one hour :of premedication.

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