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Korean J Anesthesiol. 1972 Dec;5(2):147-150. Korean. Original Article. https://doi.org/10.4097/kjae.1972.5.2.147
Shin TS , Suh KS , Lim DW , Jin SH .
Department of Anesthesiology, School of Medicine, Kyung Hee University, Seoul, Korea.
Abstract

The effect of a new analeptic, doxapram hydrochloride, on respiration has been studied in ten subjects anesthetized with thiopental or with nitrous oxide-oxygen-halothane. The results are as follows: 1) Respiratory stimulation was more pronounced in the group anesthetized with thiopental than that with nitrous oxide-oxygen-halothane. 2) The stimulatory effect lasted for four minutes. Subjects who received multiple doses of the drug, however, showed a cumulative effect. 3) Most cases showed moderate hypertensive effect and brief electrocardiographic change was observed in one of the ten.

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