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J Rheum Dis. 2016 Jun;23(3):193-197. English. Case Report. https://doi.org/10.4078/jrd.2016.23.3.193
Tag HS , Jun SM , Lee SG , Park EK , Koo DW , Kim GT .
Division of Rheumatology, Department of Internal Medicine, Kosin University College of Medicine, Busan, Korea. gtah@hanmail.net
Department of Nuclear Medicine, Kosin University College of Medicine, Busan, Korea.
Department of Rheumatology, Pusan National University Hospital, Busan, Korea.
Abstract

In systemic sclerosis, digital ulcers and gangrene are somewhat common clinical characteristics of obliterative vasculopathy. These manifestations increase morbidities, such as pain, infections, and acroosteolysis. However, patient responses to the appropriate treatments are often inadequate. We treated a patient with systemic sclerosis who had a refractory digital ulcer and gangrene with bosentan, an endothelin receptor antagonist, and observed improvement. Here we systematically review this case.

Copyright © 2019. Korean Association of Medical Journal Editors.