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J Rheum Dis. 2016 Jun;23(3):148-153. English. Review.
Seong S , Kim JH , Kim N .
Department of Pharmacology, Chonnam National University Medical School, Gwangju, Korea.
Department of Biomedical Sciences, Chonnam National University Medical School, Gwangju, Korea.

In general, bone homeostasis is maintained through the balance between bone formation and resorption. Disruption in this balance results in bone-related diseases such as osteopetrosis, osteoporosis, and rheumatoid arthritis. Often, enhanced osteoclastogenesis is followed by accelerated bone resorption that is induced by pro-inflammatory cytokines in osteoporosis or rheumatoid arthritis, and leads to bone destruction. In this review study, factors involved in osteoclast differentiation and function are discussed, and how the prevention of such factors is effective in ameliorating bone loss in osteoporosis or rheumatoid arthritis.

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