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J Rheum Dis. 2015 Oct;22(5):313-316. Korean. Case Report. https://doi.org/10.4078/jrd.2015.22.5.313
Shim HI , Park W , Kim YJ , Jung KH , Baek JH , Lim MJ , Joo K , Kwon SR .
Division of Rheumatology, Department of Internal Medicine, Inha University Hospital, Inha University School of Medicine, Incheon, Korea. rhksr@inha.ac.kr
Division of Infectious Diseases, Department of Internal Medicine, Inha University Hospital, Inha University School of Medicine, Incheon, Korea.
Department of Radiology, Inha University Hospital, Inha University School of Medicine, Incheon, Korea.
Abstract

SAPHO syndrome, characterized by synovitis, acne, pustulosis, hyperostosis, and osteitis is rare compared to other spondyloarthropathies. It is also difficult to diagnose, and treatment methods have not yet been fully identified. Approximately 72% of patients are diagnosed with at least one other disease before a final diagnosis of SAPHO syndrome. In addition, SAPHO syndrome is subject to a delayed diagnosis period of 4.5 to 9.1 years. Medications such as non-steroidal anti-inflammatory drugs, disease-modifying anti-rheumatic drugs, and tumor necrosis factor inhibitors are used in treatment of SAPHO syndrome. Bisphosphonate is also used for refractory SAPHO syndrome; however, most reports on this relate to intravenous injection of medication. The authors experienced and subsequently reported on a case involving a patient with SAPHO syndrome accompanied by fracture and infection of the left second finger who was treated with the oral biphosphonate, alendronate.

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