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J Rheum Dis. 2015 Jun;22(3):190-194. Korean. Case Report. https://doi.org/10.4078/jrd.2015.22.3.190
Oh SH , Park W , Kwon SR , Lim MJ , Joo KW , Lee OH , Lee HY , Oh SY , Jung KH .
Division of Rheumatology, Department of Internal Medicine, Inha University School of Medicine, Incheon, Korea. khjung@inha.ac.kr
Department of Radiology, Inha University School of Medicine, Incheon, Korea.
Department of Neurosurgery, Inha University School of Medicine, Incheon, Korea.
Abstract

Eosinophilic granulomatosis with polyangiitis (EGPA), previously called Churg-Strauss syndrome, is an anti-neutrophil cytoplasmic antibody associated vasculitis, accompanied by asthma, hypereosinophilia, nonfixed pulmonary infiltrates, and sinusitis. Peripheral neuropathy is common in patients with EGPA; however, a few cases of EGPA with central nervous system (CNS) involvement have been reported. A 45-year-old female referred for right side weakness and posterior neck pain was diagnosed as EGPA with subarachnoid hemorrhage and mononeuritis multiplex. She was effectively treated with a high dose glucocorticoid, cyclophosphamide, and intravenous immunoglobulin. EGPA with CNS involvement is uncommon and causes significant morbidity and mortality. Therefore more rapid and accurate diagnostic evaluation may be required. EGPA should be considered in patients with neurological symptoms and hypereosinophilia.

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