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J Rheum Dis. 2015 Jun;22(3):186-189. English. Case Report.
Na SH , Nam EY , Choe PG , Park WB , Kim NJ , Oh MD , Lee EY , Kim NH .
Department of Internal Medicine, Seoul National University Hospital, Seoul, Korea.

Tumor necrosis factor-alpha (TNF-alpha) inhibitors are increasingly used in treatment of inflammatory disorders because of their immunomodulatory efficacy. Increased risk of infection is an adverse effect of anti-TNF-alpha therapy. The incidence rate and severity of herpes zoster is significantly higher in patients on anti-TNF-alpha therapy than in the general population. The clinical presentation of varicella zoster virus infection is also often atypical in these patients. We experienced a patient who presented with a disseminated varicelliform rash while on etanercept therapy for ankylosing spondylitis.

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