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J Rheum Dis. 2014 Aug;21(4):209-213. Korean. Case Report. https://doi.org/10.4078/jrd.2014.21.4.209
Hur JA , Kim DS , Kim KH .
Department of Pediatrics, Severance Children's Hospital, Yonsei University College of Medicine, Seoul, Korea. khkim99@yuhs.ac
Abstract

Behcet's disease is a systemic vasculitis, characterized by recurrent oral aphthous ulcers, recurrent genital ulcers, skin lesion, and ocular involvement. Monoclonal antibody to the tumor necrosis factor-alpha (TNF-alpha) is considered as a possible therapeutic approach to achieve clinical improvement, preventing relapse in Behcet's disease refractory to conventional anti-inflammatory drugs or immunosuppressive durgs. We report the use of infliximab, which is one of the TNF-alpha monoclonal antibodies, in a 17-year-old girl with Behcet's disease exhibiting severe mucocutaneous, ocular and neurological involvement refractory to standard treatment.

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