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J Rheum Dis. 2014 Aug;21(4):182-186. Korean. Original Article. https://doi.org/10.4078/jrd.2014.21.4.182
Lee CJ , Sohn TY , Lee DH , Lee HR , Kim M , Kim KN .
Department of Pediatric, Hallym University Sacred Heart Hospital, Anyang, Korea. kwangnamkim@naver.com
Department of Adolescent Medicine, Hallym University Sacred Heart Hospital, Anyang, Korea.
Department of Laboratory Medicine, Hallym University Sacred Heart Hospital, Anyang, Korea.
Abstract

OBJECTIVE: The aim of this study is to investigate the association of different subgroups of juvenile rheumatoid arthritis (JRA) with human leukocyte antigen (HLA) class II DR alleles. METHODS: One hundred and nineteen Korean juvenile rheumatoid arthritis patients were classified as HLA-DRB1 allele. To assess the frequency, phenotype frequencies of all JRA cases and each subtypes were compared to those of 485 adult controls. RESULTS: HLA-DRB1*01 was associated with increased risk of JRA. Furthermore, DRB1*01 was associated with polyarticular JRA and pauciarticular JRA. The frequencies of DRB1*14 and DRB1*15 were higher in systemic JRA patients than the controls. CONCLUSION: The data of this study on Korean children with JRA suggests that HLA-DRB1*01 was associated with the susceptibility of JRA. The study should be extended to include larger numbers of patients.

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