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J Rheum Dis. 2011 Dec;18(4):306-310. Korean. Case Report. https://doi.org/10.4078/jrd.2011.18.4.306
Lee SS , Kim HO , Na JB , Lee JS , Suh YS , Cheon YH , Kang MG , Kim YE , Lee SI .
Department of Internal Medicine, Gyeongsang National University School of Medicine, Jinju, Korea. goldgu@gnu.ac.kr
Department of Radiology, Gyeongsang National University School of Medicine, Jinju, Korea.
Department of Pathology, Gyeongsang National University School of Medicine, Jinju, Korea.
Institute of Health Sciences, Gyeongsang National University School of Medicine, Jinju, Korea.
Abstract

Eosinophilic fasciitis (EF) is a rare fibrosing disorder characterized by painful swelling and induration of the limbs and trunk, characteristic histology with sclerosis and lymphocytic inflammation affecting the fascia. The cause and pathogenesis of EF are still unknown and current therapies include glucocorticoids with or without use of immunosuppressive agents. Recently, there have been several case reports documenting the efficacy of a TNF alpha inEosinophilic fasciitis (EF) is a rare fibrosing disorder characterized by painful swelling and induration of the limbs and trunk, characteristic histology with sclerosis and lymphocytic inflammation affecting the fascia. The cause and pathogenesis of EF are still unknown and current therapies include glucocorticoids with or without use of immunosuppressive agents. Recently, there have been several case reports documenting the efficacy of a TNF alpha inhibitor in EF following a steroid-resistant disease course. However, there has been no report on the experience in treatment of EF with a TNF alpha inhibitor in Korea. Hence, we report a case of steroid and methotrexate-resistant EF which was successfully treated with adalimumab, along with a review of the relevant articles.

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