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J Korean Soc Endocrinol. 2002 Oct;17(5):730-738. Korean. Case Report.
Kim JK , Chung HW , Seo HS , Kim DJ , Chung SS , Song YD , Kwon KH , Jin YM , Lee MK , Lim SK , Kim IJ , Kang HC , Park JH , Park JG .
Department of Internal Medicine, National Health Insurance Corporation Ilsan Hospital, Korea.
Department of Surgery, National Health Insurance Corporation Ilsan Hospital, Korea.
Department of Pathology, National Health Insurance Corporation Ilsan Hospital, Korea.
Department of Internal Medicine, Yonsei University College of Medicine, Korea.
Familial Cancer Clinic, National Cancer Center, Korea.
Abstract

Multiple endocrine neoplasia (MEN) type 2A is a syndrome of medullary thyroid carcinomas, pheochromocytomas and parathyroid hyperplasia. The simultaneous occurrence of medullary, and papillary, thyroid carcinomas is rare because they are derived from, apparently, different germ layers, the former from the neuroectoderm and the latter from the endoderm. We report a case of a papillary thyroid carcinoma, combined with a medullary thyroid carcinoma, in a patient with MEN type 2A. Molecular genetic studies for screening a RET proto-oncogene mutation revealed a point mutation in codon 631 on chromosome 10, which is reported as highly uncommon in MEN type 2A.

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