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Korean J Hepatol. 2010 Jun;16(2):187-191. Korean. Case Report.
Lee YN , Jeong SW , Lim JH , Ryu YS , Jeon SR , Kim SK , Jang JY , Kim YS , Kim BS , Roh MO .
Institute for Digestive Research, Endocrinology, Soonchunhyang University College of Medicine, Seoul, Korea. jeongsw@hosp.sch.ac.kr
Department of Internal Medicine, Soonchunhyang University College of Medicine, Seoul, Korea.
Abstract

Combined pegylated interferon and ribavirin therapy for chronic hepatitis C infection cause a wide range of side effects, including flu-like syndrome, hematological abnormalities, cardiovascular symptoms, gastrointestinal symptoms, pulmonary dysfunction, depression, and retinopathy. Interferon-alpha has been shown to be related to the development of various autoimmune diseases, including systemic lupus erythematosus, rheumatoid arthritis, autoimmune thyroid disease, and type 1 diabetes mellitus (DM). Type 1 DM and thyroid disease respectively develop in 0.08~2.61% and 10~15% of patients treated with combined interferon-alpha and ribavirin for chronic hepatitis C. The coexistence of type 1 DM and autoimmune thyroiditis was rarely reported. We report a case of a 33-year-old female patient with chronic hepatitis C who simultaneously developed diabetic ketoacidosis and autoimmune thyroiditis after treatment with pegylated interferon-alpha 2b and ribavirin.

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