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Korean J Hepatol. 2008 Mar;14(1):102-107. Korean. Case Report.
Lee JY , Park EB , Ahn JH , Suh SJ , Jung YK , Kim JH , Shin BK , Yang JH , Yeon JE , Byun KS .
Korea University Medical College Guro Hospital, Department of Internal Medicine, Seoul, Korea. je_yeon@hotmail.com
Korea University Medical College Guro Hospital, Department of Pathology, Seoul, Korea.
Korea University Medical College Ansan Hospital, Department of Laboratory Medicine, Ansan, Korea.
Abstract

Ticlopidine inhibits platelet aggregation and provides beneficial secondary prevention of cerebrovascular and coronary artery disease. Frequently reported adverse effects of ticlopidine include diarrhea, nausea, and rash. However, to our knowledge, there are only a few published reports of the simultaneous occurrence of cholestatic hepatitis and pure red cell aplasia. Here we report a patient with simultaneous severe cholestatic hepatitis and pure red cell aplasia associated with ticlopidine. Although these adverse effects are rare, periodic hematological and liver function tests are recommended after starting ticlopidine.

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