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Korean J Hepatol. 1997 Mar;3(1):78-84. Korean. Case Reports.
Kim DH , Jo JH , Keum MS , Choi SG , Lee CH , Kweon YO , Kim SK , Choi YW , Chung JM .

Methotrexate (MTX) has been widely used in the treatment of psoriasis and rheumatoid arthritis. But prolonged use of MTX can induce hepatic fibrosis and even cirrhosis. To date, in Korea, there have been very few reports on hepatotoxicity due to MTX, and no report on biopsy-proven chronic active hapatitis. We report one patient who developed chronic acitve hepatitis while taking long-term daily dose of MTX(10mg per day) for psoriasis for a prolonged period.

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