Degenerative disease of the spine affects all people and several distinct degenerative processes can be observed. These processes are associated with characteristic radiographic and pathologic abnormalities. Intervertebral osteochondrosis, spondylosis deformans, osteoarthritis of the facet joint, and diffuse idiopathic skeletal hyperostosis (DISH) are the major forms of degenerative diseases in lumbar spine. Ultrasound is frequently used to guide several lumbar procedures before and after operation, or just for nerve block and intra-articular injection even though fluoroscopy have been used preferentially in interventional procedures due to well visualization of the needle and of the spreading of the injections. However, more and more clinicians have applied ultrasound-guided intervention with several advantages, such as no radiation exposure, relatively inexpensive in cost, and smaller space in occupancy. We reviewed sonoanatomy and well established several ultrasound-guided interventions in lumbar spine, such as medial branch block, facet joint injection, caudal block, and lumbar epidural block.