PURPOSE: The purpose of this study is to identify relationships between acculturation, social network, and health-related quality of life (HRQOL) among Korean-Chinese immigrants. METHODS: A cross-sectional descriptive study was conducted with 147 Korean-Chinese immigrants who were residing more than 1 year in Korea. Physical and mental dimensions of HRQOL were assessed by Short Form-12 Health Survey that consisted of a physical component summary (PCS) and a mental component summary (MCS). Data were analyzed with Pearson's correlation and multiple regression. RESULTS: The mean PCS score was 41.14+/-10.72 and the mean MCS score was 49.09+/-11.31 (possible range 10-70). Depression (beta=-6.43) and Social network frequency (beta=2.44) explained 28.4% of the variance in PCS while depression (beta=-11.54) and visiting clinic/hospital (beta=-4.00) explained 34.3% of the variance in MCS. Acculturation was not significantly associated with HRQOL. CONCLUSION: This study confirmed that the social network frequency influences HRQOL among Korean-Chinese Immigrants. The findings suggest that social network analysis should be considered in the process of developing health intervention strategies for Korean-Chinese immigrants.