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Int J Oral Biol. 2019 Mar;44(1):20-26. Korean. Original Article. https://doi.org/10.11620/IJOB.2019.44.1.20
Kim Y , Park JY , Park HJ , Kim MK , Kim YI , Bae SK , Kim HJ , Bae MK .
Department of Oral Physiology, School of Dentistry, Pusan National University, Yangsan 50612, Republic of Korea. mkbae@pusan.ac.kr
Department of Orthodontics, School of Dentistry, Pusan National University, Yangsan 50612, Republic of Korea.
Department of Dental Pharmacology, School of Dentistry, Pusan National University, Yangsan 50612, Republic of Korea.
Abstract

Periodontal diseases have been associated with the development of cardiovascular diseases. Accumulating evidences have indicated that Porphyromonas gingivalis, a major periodontopathic pathogen, plays a critical role in the pathogenesis of atherosclerosis. In the present study, we demonstrated that P. gingivalis lipopolysaccharide (LPS) increases the mRNA and protein expression of matrix metalloproteinase-9 (MMP-9) in rat vascular smooth muscle cells. We showed that the MMP-9 expression induced by P. gingivalis LPS is mediated by the activation of signal transducer and activator of transcription 3 (STAT3) in vascular smooth muscle cells. Furthermore, the inhibition of STAT3 activity reduced P. gingivalis LPS-induced migration of vascular smooth muscle cells. Overall, our findings indicate that P. gingivalis LPS stimulates the migration of vascular smooth muscle cells via STAT3-mediated MMP-9 expression.

Copyright © 2019. Korean Association of Medical Journal Editors.