Journal Browser Advanced Search Help
Journal Browser Advanced search HELP
Int J Oral Biol. 2019 Mar;44(1):14-19. English. Original Article. https://doi.org/10.11620/IJOB.2019.44.1.14
Choi YJ , Lee SW .
Department of Dental Science, School of Dentistry, Chonnam National University, Gwangju 61186, Republic of Korea.
Departments of Dental Education and Periodontology, School of Dentistry, Chonnam National University, Gwangju 61186, Republic of Korea. swlee@chonnam.ac.kr
Dental Science Research Institute, School of Dentistry, Chonnam National University, Gwangju 61186, Republic of Korea.
Abstract

The present study aimed at evaluating serum immunoglobulin G (IgG) avidity to Porphyromonas gingivalis in elderly patients with mild and severe chronic periodontitis. The avidity of antibodies against P. gingivalis present in the sera of 18 patients with mild chronic periodontitis and 18 patients with severe chronic periodontitis was evaluated using an ammonium thiocyanate-dissociated enzyme-linked immunosorbent assay (ELISA). The results showed that the mean absorbance value in serum IgG antibody titers was significantly higher in the severe chronic periodontitis group than in the mild chronic periodontitis group (198 ± 35 ELISA unit [EU] vs. 142 ± 32 EU, p < 0.01). However, there was no significant difference between the two groups in antibody avidity (65 ± 57 EU vs. 54 ± 27 EU). These findings suggest that humoral immune responses to P. gingivalis between mild and severe chronic periodontitis in elderly patients are characterized by the differences in the quantity rather than the quality of the antibodies.

Copyright © 2019. Korean Association of Medical Journal Editors.